Wellness Testing • Suntree, Melbourne, Florida

ZRT Neurotransmitter Testing

A convenient dried-urine assessment of neurotransmitters, metabolites, and key pathways.

Neurotransmitters are chemical messengers used by the nervous system to relay signals between nerve cells. When patterns are out of balance, people may notice changes in sleep, mood, stress resilience, focus, and energy. ZRT offers a dried-urine approach designed to capture a fuller daily picture with multiple collections.

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What this test can—and can’t—tell you

Urine neurotransmitter markers can be helpful as biomarkers of nervous system–related physiology and metabolism, but they are not the same as directly measuring neurotransmitter activity in the brain at the synapse.

  • Neurotransmitters support many functions across the body and nervous system. (Cleveland Clinic)
  • ZRT’s approach uses multiple collections and includes parent neurotransmitters plus downstream metabolites. (ZRT)
  • Urinary neurotransmitter testing has recognized limitations and should be interpreted clinically. (Neuroscience & Biobehavioral Reviews)

What ZRT Neurotransmitter Testing Measures

ZRT describes its neurotransmitter testing as a combination of parent neurotransmitters and downstream metabolites to identify systemic patterns and improve interpretive clarity. The test kit options and analytes may include serotonin markers (e.g., 5-HT and 5-HIAA), dopamine markers (e.g., dopamine and metabolites), catecholamines (e.g., epinephrine and norepinephrine), inhibitory/excitatory markers (e.g., GABA and glutamate), and related pathway markers depending on the kit ordered.

When patients commonly ask about this test

  • Sleep disruption, persistent fatigue, “wired but tired” feelings
  • Stress load and resilience concerns
  • Low mood, anxious feelings, irritability (clinical evaluation still required)
  • Focus/attention concerns and brain fog
These symptoms can have many causes. Testing is most useful when paired with a medical history, medication/supplement review, and (when appropriate) other labs.

How collection works (dried urine)

ZRT states it provides a “24-hour equivalent in four easy collections,” using dried urine strips that are collected up to four times during the day and are shelf-stable for mailing.

  • At-home collection on filter strips (up to 4 collections/day)
  • Easy shipping (no jug collection)
  • Designed to reflect daily variation patterns
Follow the kit instructions carefully (timing, foods/meds/supplements, and hydration guidance if provided by your clinician).

Interpreting Results (Clinically, Not in Isolation)

Neurotransmitter biology is complex. Educational medical resources explain that neurotransmitters act as chemical messengers, and many body systems can influence related symptoms. Urinary neurotransmitter markers may offer useful biomarker insights, but published reviews also describe limitations and challenges of urinary neurotransmitter testing—so interpretation should be individualized and clinically grounded.

Credible Sources

We base education content on recognized medical organizations and peer-reviewed literature:

This page is for education and does not replace medical diagnosis or emergency care.

Frequently Asked Questions

Clear answers with references to trusted medical sources.

Neurotransmitters are chemical messengers that help transmit signals between nerve cells and influence many functions throughout the nervous system and body. Source: Cleveland Clinic (see “Credible Sources” above).
ZRT describes neurotransmitter testing that includes a range of parent neurotransmitters plus downstream metabolites, using a dried-urine method with multiple collections to support pattern interpretation. Source: ZRT Laboratory (see “Credible Sources” above).
Not directly. Urinary neurotransmitter markers can provide biomarker information, but they do not directly quantify neurotransmitter activity in the brain at the synapse. Published reviews discuss clinical uses as biomarkers along with limitations and interpretive challenges. Source: Neuroscience & Biobehavioral Reviews (see “Credible Sources” above).
ZRT describes collecting urine on filter strips up to four times during the day (a “24-hour equivalent in four easy collections”) and mailing the dried strips back for analysis. Source: ZRT Laboratory (see “Credible Sources” above).
Results are best used alongside your medical history, symptoms, and other labs to guide a personalized plan. Depending on your situation, your clinician may discuss sleep and stress strategies, nutrition, and targeted support when appropriate. Sources: Cleveland Clinic (neurotransmitter function) + published review on urinary biomarkers.

Request Testing

Use the form below for non-urgent requests. If you are experiencing an emergency, call 911. (You can connect this form to Gravity Forms or your preferred backend later.)

What to expect

We’ll review your goals, symptoms, current medications/supplements, and whether neurotransmitter testing makes sense in your care plan.

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